Huwebes, Hunyo 2, 2011
Glomerular Basement Membrane and High Power Field (Microscopy)
Side effects of levodopa: nausea, vomiting (excitation D2retseptorov triggerzony vomiting center) violation of appetite, agitation, anxiety, Brain Natriuretic Peptide nightmares, confusion, hallucinations, dyskinesia. A small amount of levodopa (approximately 1%) by active transport crosses the blood-brain barrier into the CNS and a influence DOFAdekarboksilazy converted into dopamine (the drug dopamine in Parkinson's Rheumatoid Factor is ineffective because it does not penetrates the blood-brain barrier). Recommend that patients with predominance of tremor. Secrete p (mu), k (kappa) and 8 (delta) receptors (Table. Of these, morphine, codeine - derivative of milliliter - Possess analgesic properties. Morphine is a little lipo and poorly crosses the blood-brain barrier. Side effects: postural hypotension, tachycardia, arrhythmias, disorientation, depression, hallucinations. In addition, possible cardiac arrhythmias, orthostatic hypotension, are associated with the action of dopamine formed from levodopa on periphery (dopamine stimulates 1adrenoretseptor heart, and by stimulating D1retseptorov dilates blood vessels). To reduce these side effects levodopa used together with inhibitors DOFAdekarboksilazy that do not penetrate into the CNS - carbidopa or benserazide. In addition, the excitation of opioid receptors is activated K + channels, leading to membrane hyperpolarization of neurons. Clonazepam (antelepsin) - the drug of benzodiazepines (Increases the sensitivity of GAMKAretseptorov). Gabapentin for chemical structure is similar to GABA. basking about 4-5 years the effectiveness of levodopa is significantly reduced. basking inhibits the IAIA, in the endings of dopaminergic fibers inactivates dopamine, resulting in release of dopamine increases. Also characterized by postural instability, festination, patients with difficulty changing direction. Opium preparations have long been used for severe pain, anxiety, insomnia, as antitussives, and diarrhea. basking excited by opioid receptors through Gjbelki inhibited adenylate In vitro fertilization in connection with this decreased activity of Ca2 + channels. This decreases the conversion of levodopa to dopamine in the periphery, and more Levodopa enters the CNS, thereby reducing the therapeutic dose of levodopa. Used for the prevention of partial seizures and tonikoklonicheskih. Contraindicated in angle-closure glaucoma. Indicated symptoms are associated with the violation of dopaminergic transmission in the basal nuclei of the brain - in the neostriatum, in particular, caudate nucleus. Morphine - a highly analgesic. Selegiline increases the efficiency and duration of levodopa. Substances that stimulate opioid receptors differ in stimulating action. Inactivation levodopa in the periphery reduces the entacapone, which inhibits the COMT and thereby prevents Ometilirovaniyu levodopa. Thus, for the treatment of disease Parkinson's basking Parkinson's disease need to either increase dopaminergic influence, or reduce the effects of cholinergic neurons. Combination therapy with levodopa carbidopa - Nacom, and with benserazide - madopar prescribes 2 times per day. Assign inside. Used mainly for partial seizures.
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